2-[6-(2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

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Chemical Name:2-[6-(2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester
CAS No.:858346-80-2
Molecular Formula:C₆₀H₇₇F₃O₁₀Si
Molecular Weight:1043.35
Hs Code.:

2-[6-(2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4<i>H</i>-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

Synonyms:2-[6-(2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

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Chemical Property of 2-[6-(2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

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Technology Process of 2-[6-(2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

There total 9 articles about 2-[6-(2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 858346-79-9
2-[(2R,6S)-6-((2R,4R,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-5-methyl-7-{(2S,6S)-6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

: 407-25-0
trifluoroacetic anhydride

: 858346-80-2
2-[6-(2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

Guidance literature:: With pyridine; In dichloromethane; for 0.5h;
DOI:10.1021/ol0510769

Reference yield:

: 851594-64-4
trifluoromethanesulfonic acid 4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl ester

: 858346-80-2
2-[6-(2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 363 mg / K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran; dimethylformamide; H₂O / 3 h / 23 °C

2: 88 percent / HF*pyridine; pyridine / tetrahydrofuran / 1 h / 20 °C

3: 92 percent / pyridine / CH₂Cl₂ / 0.5 h

With pyridine; potassium phosphate; pyridine hydrogenfluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki-Miyaura reaction;
DOI:10.1021/ol0510769

Reference yield:

: 851594-70-2
2-{(2R,6S)-6-[(2R,4R,5S)-7-((2S,6R)-6-Allyl-tetrahydro-pyran-2-yl)-2-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-methyl-heptyl]-tetrahydro-pyran-2-yl}-2-methyl-propionic acid benzyl ester

: 858346-80-2
2-[6-(2-(tert-butyl-dimethyl-silanyloxy)-5-methyl-7-{6-[3-(4-oxo-2,2-diphenyl-4H-benzo[1,3]dioxin-5-yl)-propyl]-tetrahydro-pyran-2-yl}-4-trifluoroacetoxy-heptyl)-tetrahydro-pyran-2-yl]-2-methyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2: tetrahydrofuran / 17 h / 20 °C

3: 363 mg / K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran; dimethylformamide; H₂O / 3 h / 23 °C

4: 88 percent / HF*pyridine; pyridine / tetrahydrofuran / 1 h / 20 °C

5: 92 percent / pyridine / CH₂Cl₂ / 0.5 h

With pyridine; potassium phosphate; pyridine hydrogenfluoride; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 3: Suzuki-Miyaura reaction;
DOI:10.1021/ol0510769