(2R,3S)-6-O--3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol

Base Information

Chemical Name:(2R,3S)-6-O--3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol
CAS No.:167702-98-9
Molecular Formula:C₂₂H₃₆O₅S₂Si
Molecular Weight:472.742
Hs Code.:

(2R,3S)-6-O-<dimethyl-(1,1,2-trimethylpropyl)silyl>-3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol

Synonyms:(2R,3S)-6-O--3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol

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Chemical Property of (2R,3S)-6-O--3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol

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Technology Process of (2R,3S)-6-O--3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol

There total 6 articles about (2R,3S)-6-O--3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 98-59-9
p-toluenesulfonyl chloride

: 167702-97-8
(2R,3S)-6-O--3-methylthio-hex-4-yn-1,2,6-triol

: 167702-98-9
(2R,3S)-6-O--3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃;
DOI:10.1016/0040-4039(93)88072-Q

Reference yield:

: 67373-56-2
chlorodimethyl(1,1,2-trimethylpropyl)silane

: 167702-98-9
(2R,3S)-6-O--3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / NaH / tetrahydrofuran / 0 °C

2: 80 percent / Red-Al / tetrahydrofuran / 0 °C

3: 85 percent / (-)-DET, Ti(OtBu)4, t-BuOOH, molecular sieves 4 Angstroem / CH₂Cl₂ / -20 °C

4: 95 percent / methanol / 0 °C

5: 80 percent / pyridine, DMAP / CH₂Cl₂ / 0 °C

With pyridine; titanium(IV) tetrabutoxide; tert.-butylhydroperoxide; dmap; 4 A molecular sieve; sodium hydride; (-)-diethyl tartrate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0040-4039(93)88072-Q

Reference yield:

: 152844-30-9
6-O-silyl-hex-2,4-diyn-1,6-diol

: 167702-98-9
(2R,3S)-6-O--3-methylthio-1-O-(4-methylbenzenesulfonyl)-hex-4-yn-1,2,6-triol

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Red-Al / tetrahydrofuran / 0 °C

2: 85 percent / (-)-DET, Ti(OtBu)4, t-BuOOH, molecular sieves 4 Angstroem / CH₂Cl₂ / -20 °C

3: 95 percent / methanol / 0 °C

4: 80 percent / pyridine, DMAP / CH₂Cl₂ / 0 °C

With pyridine; titanium(IV) tetrabutoxide; tert.-butylhydroperoxide; dmap; 4 A molecular sieve; (-)-diethyl tartrate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0040-4039(93)88072-Q