5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-hydroxylbenzoic acid

Base Information

Chemical Name:5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-hydroxylbenzoic acid
CAS No.:1562194-07-3
Molecular Formula:C₂₃H₁₅F₅N₂O₃
Molecular Weight:462.376
Hs Code.:

Synonyms:5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-hydroxylbenzoic acid

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Chemical Property of 5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-hydroxylbenzoic acid

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Technology Process of 5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-hydroxylbenzoic acid

There total 9 articles about 5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-hydroxylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.9%

: 1562195-30-5
methyl 5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-methoxybenzoate

: 1562194-07-3
5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-hydroxylbenzoic acid

Guidance literature:: With boron tribromide; In dichloromethane; at -30 - 10 ℃;

Reference yield:

: 1562195-07-6
methyl 4-(1-(2-bromo-6-(trifluoromethyl)benzyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

: 1562194-07-3
5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-hydroxylbenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 16 h / 100 °C

2: boron tribromide / dichloromethane / -30 - 10 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; boron tribromide; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 341-23-1
4-fluoro-1H-indazole

: 1562194-07-3
5-fluoro-4-(4-fluoro-1-(2-methyl-6-(trifluoromethyl)benzyl)-1H-indazol-3-yl)-2-hydroxylbenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 0 - 20 °C

2: toluene-4-sulfonic acid / tetrahydrofuran / 6 h / Reflux

3: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

4: hydrogenchloride; methanol / 14 h / Reflux

5: caesium carbonate / N,N-dimethyl-formamide / 3 h / 10 °C

6: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 16 h / 100 °C

7: boron tribromide / dichloromethane / -30 - 10 °C

With hydrogenchloride; methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; boron tribromide; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3: |Suzuki Coupling;