(S)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide

Base Information

• Chemical Name: (S)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide
• CAS No.: 125405-96-1
• Molecular Formula: C₂₁H₂₂N₂O₃S₂
• Molecular Weight: 414.549
• Mol file: 125405-96-1.mol

Synonyms:(S)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide

Chemical Property of (S)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide

There total 1 articles about (S)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

(R)-1-phenyl-ethyl-amine (3886-69-9) + N-(4-methylbenzenesulfonyl) phenyl sulfonimidoyl chloride (89538-92-1) → (S)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide (125405-96-1) + (R)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide (125405-95-0)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1246/bcsj.62.1167

Reference yield: 77.0%

(S)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide (125405-96-1) → (S)-N-(p-tolylsulfonyl)benzenesulfonimidamide (125406-00-0)

Guidance literature:

In trifluoroacetic acid; at 35 ℃; for 40h;

DOI:10.1246/bcsj.62.1167

Reference yield:

(S)-N-<(S)-α-methylbenzyl>-N'(p-tolylsulfonyl)benzenesulfonimidamide (125405-96-1) → C19H22N2O3S2

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / trifluoroacetic acid / 40 h / 35 °C

2: 93 percent / t-butyl hypochlorite, CH₃ONa / methanol / ice cooling

3: 1.) Se powder / 1.) CH₂Cl₂, Rt, 3.5 h; 2.) CH₂Cl₂, 0 deg C 24 h, then Rt, 1 h

With selenium; tert-butylhypochlorite; sodium methylate; In methanol; trifluoroacetic acid;

DOI:10.1246/bcsj.62.1167

upstream raw materials:

(R)-1-phenyl-ethyl-amine

N-(4-methylbenzenesulfonyl) phenyl sulfonimidoyl chloride

Downstream raw materials:

(S)-N-(p-tolylsulfonyl)benzenesulfonimidamide