Technology Process of Bz-L-Ile-L-Glu(OMe)-Gly-OH
There total 6 articles about Bz-L-Ile-L-Glu(OMe)-Gly-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 2h;
Ambient temperature;
DOI:10.1248/cpb.35.2698
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diethyl phosphorocyanidate, triethylamine / dimethylformamide / 0 deg C, 2 h, room temp., overnight
2: 10percent hydrogen chloride / ethyl acetate / 20 h / Ambient temperature
3: 44 percent / diethyl phosphorocyanidate, triethylamine / dimethylformamide / 0 deg C, 2 h, room temp., overnight
4: 87 percent / H2 / 5percent Pd-C / methanol / 5 h / Ambient temperature
5: 74 percent / triethylamine / tetrahydrofuran / 0 deg C, 1 h, room temp., 2 h
6: 99 percent / trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
With
hydrogenchloride; diethyl cyanophosphonate; hydrogen; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.2698
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 10percent hydrogen chloride / ethyl acetate / 20 h / Ambient temperature
2: 44 percent / diethyl phosphorocyanidate, triethylamine / dimethylformamide / 0 deg C, 2 h, room temp., overnight
3: 87 percent / H2 / 5percent Pd-C / methanol / 5 h / Ambient temperature
4: 74 percent / triethylamine / tetrahydrofuran / 0 deg C, 1 h, room temp., 2 h
5: 99 percent / trifluoroacetic acid / CH2Cl2 / 2 h / Ambient temperature
With
hydrogenchloride; diethyl cyanophosphonate; hydrogen; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.2698
