Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester
CAS No.:316139-77-2
Molecular Formula:C₃₂H₄₀Cl₃NO₁₇
Molecular Weight:817.025
Hs Code.:

Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester

Synonyms:Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester

Suppliers and Price of Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester

There total 6 articles about Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 541-88-8
Chloroacetic anhydride

: 316139-76-1
{(2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-Acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-acetic acid methyl ester

: 316139-77-2
Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/S0960-894X(00)00497-2

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 316139-77-2
Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / PTS / acetonitrile / 12 h / 20 °C

2.1: 65 percent / Hg(CN)2 / benzene; nitromethane / 12 h / 40 - 45 °C

3.1: 94 percent / 1 M aq. NaOMe / methanol; CH₂Cl₂ / 2 h / 20 °C / pH 10.0

4.1: n-Bu₂SnO / methanol / 3 h / Heating

4.2: 57 percent / n-Bu₄NI / 48 h / 60 - 65 °C

5.1: 65 percent / NaHCO₃ / dimethylformamide / 12 h / 20 °C

With sodium methylate; mercury(II) cyanide; pyridinium p-toluenesulfonate; di(n-butyl)tin oxide; sodium hydrogencarbonate; In methanol; nitromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene; 1.1: acetalization / 2.1: glycosylation / 3.1: Deacetylation / 4.1: Metallation / 5.1: Acylation;
DOI:10.1016/S0960-894X(00)00497-2

Reference yield:

: 6082-22-0
methyl α-D-N-acetylgalactosamine

: 316139-77-2
Chloro-acetic acid (2R,3R,4S,5S,6R)-2-[(4aR,6S,7R,8R,8aR)-7-acetylamino-6-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-5-(2-chloro-acetoxy)-6-(2-chloro-acetoxymethyl)-4-methoxycarbonylmethoxy-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / PTS / acetonitrile / 12 h / 20 °C

2.1: 65 percent / Hg(CN)2 / benzene; nitromethane / 12 h / 40 - 45 °C

3.1: 94 percent / 1 M aq. NaOMe / methanol; CH₂Cl₂ / 2 h / 20 °C / pH 10.0

4.1: n-Bu₂SnO / methanol / 3 h / Heating

4.2: 57 percent / n-Bu₄NI / 48 h / 60 - 65 °C

5.1: 65 percent / NaHCO₃ / dimethylformamide / 12 h / 20 °C

With sodium methylate; mercury(II) cyanide; pyridinium p-toluenesulfonate; di(n-butyl)tin oxide; sodium hydrogencarbonate; In methanol; nitromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene; 1.1: acetalization / 2.1: glycosylation / 3.1: Deacetylation / 4.1: Metallation / 5.1: Acylation;
DOI:10.1016/S0960-894X(00)00497-2