(R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)quinolin-5-yloxy)ethyl)pyrrolidin-2-one

Base Information

Chemical Name:(R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)quinolin-5-yloxy)ethyl)pyrrolidin-2-one
CAS No.:1421339-71-0
Molecular Formula:C₂₄H₂₆N₂O₅
Molecular Weight:422.481
Hs Code.:

Synonyms:(R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)quinolin-5-yloxy)ethyl)pyrrolidin-2-one

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Chemical Property of (R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)quinolin-5-yloxy)ethyl)pyrrolidin-2-one

Chemical Property:

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Technology Process of (R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)quinolin-5-yloxy)ethyl)pyrrolidin-2-one

There total 10 articles about (R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)quinolin-5-yloxy)ethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1319736-51-0
(4R)-4-((S)-1-hydroxyethyl)-1-((R)-1-phenylethyl)pyrrolidine-2-one

: 1421341-11-8
7-(3,4,5-trimethoxyphenyl)quinolin-5-ol

: 1421339-71-0
(R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)quinolin-5-yloxy)ethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 6 h / 20 °C

2: trifluoroacetic acid / 1.25 h / 150 °C / Microwave irradiation

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1421341-21-0
C₃₂H₃₄N₂O₅

: 1421339-71-0
(R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)quinolin-5-yloxy)ethyl)pyrrolidin-2-one

Guidance literature:: With trifluoroacetic acid; at 150 ℃; for 1.25h; Microwave irradiation;

Reference yield:

: 53560-33-1
3,4,5-trimethoxyphenylacetylene

: 1421339-71-0
(R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)quinolin-5-yloxy)ethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; bis(triphenylylphosphine)palladium(II) dichloride; triethylamine / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere

2.1: sulfuric acid; mercury dichloride / 1.75 h / 60 °C

2.2: 1 h / 25 °C

3.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 6 h / 20 °C

4.1: trifluoroacetic acid / 1.25 h / 150 °C / Microwave irradiation

With copper(l) iodide; di-tert-butyl-diazodicarboxylate; sulfuric acid; bis(triphenylylphosphine)palladium(II) dichloride; triethylamine; triphenylphosphine; trifluoroacetic acid; mercury dichloride; In tetrahydrofuran; dichloromethane;