1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-[(pentafluorophenoxy)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine

Base Information

Chemical Name:1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-[(pentafluorophenoxy)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine
CAS No.:928761-47-1
Molecular Formula:C₃₃H₃₁F₅N₂O₆SSi
Molecular Weight:706.762
Hs Code.:

Synonyms:1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-[(pentafluorophenoxy)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine

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Chemical Property of 1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-[(pentafluorophenoxy)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine

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Technology Process of 1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-[(pentafluorophenoxy)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine

There total 3 articles about 1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-[(pentafluorophenoxy)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 135192-53-9
pentafluorophenoxythiocarbonyl chloride

: 101527-40-6
5'-O-tert-butyldiphenylsilylthymidine

: 928761-47-1
1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-[(pentafluorophenoxy)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine

Guidance literature:: With pyridine; In benzene; at 80 ℃; for 2h;
DOI:10.1016/j.carres.2006.11.015

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 928761-47-1
1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-[(pentafluorophenoxy)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 82.5 percent / imidazole / dimethylformamide / 2 h / 0 °C

2: 87 percent / pyridine / benzene / 2 h / 80 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.carres.2006.11.015

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 928761-47-1
1-[5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-[(pentafluorophenoxy)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 82.5 percent / imidazole / dimethylformamide / 2 h / 0 °C

2: 87 percent / pyridine / benzene / 2 h / 80 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.carres.2006.11.015