<1S-(1R,2S,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-(4-thiazolyl)-L-alaninamide

Base Information

Chemical Name:<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-(4-thiazolyl)-L-alaninamide
CAS No.:142103-42-2
Molecular Formula:C₃₃H₅₁N₅O₇S₂
Molecular Weight:693.929
Hs Code.:

Synonyms:<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-(4-thiazolyl)-L-alaninamide

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Chemical Property of <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-(4-thiazolyl)-L-alaninamide

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Technology Process of <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-(4-thiazolyl)-L-alaninamide

There total 5 articles about <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-(4-thiazolyl)-L-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 122621-77-6
(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

: 142103-60-4
(S)-2-[(S)-2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-3-thiazol-4-yl-propionic acid

: 142103-42-2
<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-(4-thiazolyl)-L-alaninamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm00092a006

Reference yield:

: 124278-39-3
N-(4-MorpholinYlsulfonyl)-L-phenylalanine

: 142103-42-2
<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-(4-thiazolyl)-L-alaninamide

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / dimethylformamide / 0 - 20 °C

2: 80 percent / aq. NaOH / methanol

3: 69 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006

Reference yield:

: 142103-58-0
(S)-2-tert-Butoxycarbonylamino-3-thiazol-4-yl-propionic acid benzyl ester

: 142103-42-2
<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-(4-thiazolyl)-L-alaninamide

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / HCl (gas) / CH₂Cl₂; methanol / Ambient temperature

2: 73 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC), triethylamine / dimethylformamide / 0 - 20 °C

3: 80 percent / aq. NaOH / methanol

4: 69 percent / N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006