(2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate

Base Information

Chemical Name:(2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate
CAS No.:1415550-83-2
Molecular Formula:C₂₇H₂₈N₂O₄
Molecular Weight:444.53
Hs Code.:

Synonyms:(2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate

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Chemical Property of (2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate

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Technology Process of (2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate

There total 5 articles about (2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1415550-73-0
(S)-dibenzyl (5-oxo-5-phenylpentane-1,4-diyl)dicarbamate

: 1415550-83-2
(2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate

Guidance literature:: With triethylsilane; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 0.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo302181k

Reference yield:

: 1415550-82-1
C₂₃H₂₉N₃O₆

: 1415550-83-2
(2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -78 - 0 °C / Inert atmosphere

2: triethylsilane; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo302181k

Reference yield:

: 3184-13-2,36630-89-4
L-ornithine hydrochloride

: 1415550-83-2
(2S,3S)-benzyl 3-(benzyloxycarbonylamino)-2-phenylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrahydrofuran / 20 °C / Inert atmosphere

2: triethylamine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 6.5 h / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / -78 - 0 °C / Inert atmosphere

4: triethylsilane; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; sodium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo302181k