6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine

Base Information

Chemical Name:6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine
CAS No.:1265221-86-0
Molecular Formula:C₁₇H₂₁IN₄O₂Si
Molecular Weight:468.369
Hs Code.:

Synonyms:6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine

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Chemical Property of 6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine

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Technology Process of 6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine

There total 5 articles about 6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1265221-85-9
9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine

: 1265221-86-0
6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine

Guidance literature:: 9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; zinc(II) chloride; In tetrahydrofuran; at 90 ℃; for 1h; Inert atmosphere; Microwave irradiation;

With iodine; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere;
DOI:10.1021/ol103057k

Reference yield:

: 6504-64-9
6-chloro-9-(methoxymethyl)-9H-purine

: 1265221-86-0
6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 °C / Inert atmosphere

1.2: 1.33 h / -78 °C / Inert atmosphere

2.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere

2.2: 14 h / 45 °C / Inert atmosphere

3.1: palladium on carbon; ammonium formate / tetrahydrofuran; methanol / 0.5 h / 45 °C / Inert atmosphere

4.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; zinc(II) chloride / tetrahydrofuran / 1 h / 90 °C / Inert atmosphere; Microwave irradiation

4.2: 0 - 25 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; palladium on carbon; ammonium formate; zinc(II) chloride; In tetrahydrofuran; methanol; hexane; 2.2: Negishi coupling reaction;
DOI:10.1021/ol103057k

Reference yield:

: 1265221-82-6
6-chloro-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purine

: 1265221-86-0
6-iodo-9-(methoxymethyl)-8-(3-methoxyphenyl)-2-(trimethylsilyl)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere

1.2: 14 h / 45 °C / Inert atmosphere

2.1: palladium on carbon; ammonium formate / tetrahydrofuran; methanol / 0.5 h / 45 °C / Inert atmosphere

3.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; zinc(II) chloride / tetrahydrofuran / 1 h / 90 °C / Inert atmosphere; Microwave irradiation

3.2: 0 - 25 °C / Inert atmosphere

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; palladium on carbon; ammonium formate; zinc(II) chloride; In tetrahydrofuran; methanol; 1.2: Negishi coupling reaction;
DOI:10.1021/ol103057k