α-deutero-5-(tert-butyldimethylsilyl)-2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

Base Information

Chemical Name:α-deutero-5-(tert-butyldimethylsilyl)-2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide
CAS No.:1425052-61-4
Molecular Formula:C₁₉H₂₂F₇NOSi
Molecular Weight:442.456
Hs Code.:

Synonyms:α-deutero-5-(tert-butyldimethylsilyl)-2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

Suppliers and Price of α-deutero-5-(tert-butyldimethylsilyl)-2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of α-deutero-5-(tert-butyldimethylsilyl)-2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of α-deutero-5-(tert-butyldimethylsilyl)-2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

There total 2 articles about α-deutero-5-(tert-butyldimethylsilyl)-2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1425052-36-3
α-deutero-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)isobutyramide

: 708208-01-9
1-bromo-2-(tert-butyldimethylsilyl)acetylene

: 1425052-61-4
α-deutero-5-(tert-butyldimethylsilyl)-2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

Guidance literature:: With bis(η3-allyl-μ-chloropalladium(II)); C₂₃H₃₃N₂⁽¹⁺⁾*BF₄^(1-); caesium carbonate; In diethyl ether; at 20 - 85 ℃; for 8.08333h; Schlenk technique; Inert atmosphere;
DOI:10.1021/ja400648w

Reference yield:

: 651-83-2
4-trifluoromethyl-2,3,5,6-tetrafluoroaniline

: 1425052-61-4
α-deutero-5-(tert-butyldimethylsilyl)-2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / toluene / 12.5 h / 0 - 20 °C / Reflux; Inert atmosphere

2: bis(η3-allyl-μ-chloropalladium(II)); C23H33N2(1+)*BF4(1-); caesium carbonate / diethyl ether / 8.08 h / 20 - 85 °C / Schlenk technique; Inert atmosphere

With oxalyl dichloride; bis(η3-allyl-μ-chloropalladium(II)); C₂₃H₃₃N₂⁽¹⁺⁾*BF₄^(1-); caesium carbonate; In diethyl ether; toluene;
DOI:10.1021/ja400648w