(R,E)-1-(2-(4-fluorostyryl)-3,4,5-trimethoxyphenylsulfinyl)-2-methoxynaphthalene

Base Information

Chemical Name:(R,E)-1-(2-(4-fluorostyryl)-3,4,5-trimethoxyphenylsulfinyl)-2-methoxynaphthalene
CAS No.:1370407-91-2
Molecular Formula:C₂₈H₂₅FO₅S
Molecular Weight:492.568
Hs Code.:

Synonyms:(R,E)-1-(2-(4-fluorostyryl)-3,4,5-trimethoxyphenylsulfinyl)-2-methoxynaphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-1-(2-(4-fluorostyryl)-3,4,5-trimethoxyphenylsulfinyl)-2-methoxynaphthalene

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Technology Process of (R,E)-1-(2-(4-fluorostyryl)-3,4,5-trimethoxyphenylsulfinyl)-2-methoxynaphthalene

There total 2 articles about (R,E)-1-(2-(4-fluorostyryl)-3,4,5-trimethoxyphenylsulfinyl)-2-methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1370407-74-1
(E)-1-bromo-2-(4-fluorostyryl)-3,4,5-trimethoxybenzene

: 155135-07-2
(-)-(1R,2S,5R)-menthyl (S)-2-methoxynaphthalene-1-sulfinate

: 1370407-91-2
(R,E)-1-(2-(4-fluorostyryl)-3,4,5-trimethoxyphenylsulfinyl)-2-methoxynaphthalene

Guidance literature:: (E)-1-bromo-2-(4-fluorostyryl)-3,4,5-trimethoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

(-)-(1R,2S,5R)-menthyl (S)-2-methoxynaphthalene-1-sulfinate; In tetrahydrofuran; at -78 ℃; Inert atmosphere;
DOI:10.1021/jo3003562

Reference yield:

: 1334544-18-1
(E)-4-(4-fluorostyryl)benzaldehyde

: 1370407-61-6
C₁₄H₂₂BrO₆P

: 1370407-91-2
(R,E)-1-(2-(4-fluorostyryl)-3,4,5-trimethoxyphenylsulfinyl)-2-methoxynaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; mineral oil; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jo3003562