(E)-methyl 2-(N-(4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoyl)-N-methylsulfamoyl)benzoate

Base Information

Chemical Name:(E)-methyl 2-(N-(4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoyl)-N-methylsulfamoyl)benzoate
CAS No.:1357178-87-0
Molecular Formula:C₂₀H₁₉IN₂O₆S
Molecular Weight:542.351
Hs Code.:

Synonyms:(E)-methyl 2-(N-(4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoyl)-N-methylsulfamoyl)benzoate

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Chemical Property of (E)-methyl 2-(N-(4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoyl)-N-methylsulfamoyl)benzoate

Chemical Property:

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Technology Process of (E)-methyl 2-(N-(4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoyl)-N-methylsulfamoyl)benzoate

There total 5 articles about (E)-methyl 2-(N-(4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoyl)-N-methylsulfamoyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₁H₉ClINO₂

: methyl (2-methylsulfamoyl)benzoate

: 1357178-87-0
(E)-methyl 2-(N-(4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoyl)-N-methylsulfamoyl)benzoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1039/c2cc15670a

Reference yield:

: 139115-67-6
ethyl (E)-4--4-oxobut-2-enoate

: 1357178-87-0
(E)-methyl 2-(N-(4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoyl)-N-methylsulfamoyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: ethanol; potassium hydroxide / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

With oxalyl dichloride; ethanol; sodium hydride; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2cc15670a

Reference yield:

: 615-43-0
2-iodophenylamine

: 1357178-87-0
(E)-methyl 2-(N-(4-((2-iodophenyl)(methyl)amino)-4-oxobut-2-enoyl)-N-methylsulfamoyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 0.33 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: ethanol; potassium hydroxide / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

With 4-methyl-morpholine; oxalyl dichloride; ethanol; sodium hydride; triethylamine; N,N-dimethyl-formamide; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; potassium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2cc15670a