C₁₃H₁₆O₃

Base Information

• Chemical Name: C₁₃H₁₆O₃
• CAS No.: 1417783-28-8
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.268
• Mol file: 1417783-28-8.mol

Synonyms:C₁₃H₁₆O₃

Chemical Property of C₁₃H₁₆O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₃H₁₆O₃

There total 1 articles about C₁₃H₁₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(benzyloxymethyl)triphenylphosphonium bromide + 4-oxobutanoic acid methyl ester (13865-19-5) → C13H16O3 (1417783-24-4) + C13H16O3 (1417783-28-8)

Guidance literature:

(benzyloxymethyl)triphenylphosphonium bromide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - -40 ℃; for 0.5h;

4-oxobutanoic acid methyl ester; In tetrahydrofuran; toluene; at -78 - 25 ℃; for 0.5h; Overall yield = 60 %; Overall yield = 5.28 g; Optical yield = 54.545 %de;

DOI:10.1021/jm3014376

Reference yield: 99.0%

C13H16O3 (1417783-28-8) → trans-5-(benzyloxy)pent-4-enoic acid

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 0 - 20 ℃; for 2h;

DOI:10.1021/jm3014376

Reference yield:

C13H16O3 (1417783-28-8) → C29H32N4O6 (1417782-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; water; methanol / 2 h / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 16 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/jm3014376

upstream raw materials:

4-oxobutanoic acid methyl ester

Downstream raw materials:

C₂₉H₃₂N₄O₆

C₂₂H₂₄N₂O₅

Refernces