8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole

Base Information

Chemical Name:8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole
CAS No.:934540-72-4
Molecular Formula:C₁₉H₁₆ClN₃O₂S
Molecular Weight:385.874
Hs Code.:

Synonyms:8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole

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Chemical Property of 8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole

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Technology Process of 8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole

There total 13 articles about 8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 934542-58-2
5-(3-ethanesulfonyl-phenyl)-3-methyl-7,9-dihydro-dipyrido[2,3-b;4',3'-d]pyrrol-8-one

: 934540-72-4
8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole

Guidance literature:: With N,N-dimethyl-aniline; trichlorophosphate; at 108 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.01.095

Reference yield: 75.0%

: 934542-63-9
5-[3-(ethylsulfonyl)phenyl]-7-(4-methoxybenzyl)-3-methyl-7,9-dihydro-dipyrido[2,3-b;4',3'-d]pyrrol-8-one

: 934540-72-4
8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole

Guidance literature:: With tetramethlyammonium chloride; trichlorophosphate; at 100 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tetlet.2010.01.095

Reference yield:

: 934542-56-0
7-benzyl-5-iodo-3-methyl-7,9-dihydro-dipyrido[2,3-b;4',3'-d]pyrrol-8-one

: 934540-72-4
8-chloro-5-(3-ethanesulfonyl-phenyl)-3-methyl-9H-dipyrido[2,3-b;4',3'-d]pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.33 h / 150 °C / Microwave irradiation; Inert atmosphere

2.1: Reflux

3.1: hydrogen / 10 wt% Pd(OH)2 on carbon / acetic acid / 4 h / 36 °C

4.1: N,N-dimethyl-aniline; trichlorophosphate / 16 h / 108 °C / Inert atmosphere

4.2: Cooling with ice

With hydrogen; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; In 1,4-dioxane; acetic acid;