1-cyclopropyl-4-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Base Information

Chemical Name:1-cyclopropyl-4-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine
CAS No.:1418296-67-9
Molecular Formula:C₂₈H₃₆FN₅Si
Molecular Weight:489.711
Hs Code.:

Synonyms:1-cyclopropyl-4-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

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Chemical Property of 1-cyclopropyl-4-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-cyclopropyl-4-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

There total 12 articles about 1-cyclopropyl-4-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27374-25-0
[(1-Ethoxycyclopropyl)oxy]trimethylsilane

: 1418296-61-3
1-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-pyridin-2-yl}piperazine

: 1418296-67-9
1-cyclopropyl-4-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Guidance literature:: [(1-Ethoxycyclopropyl)oxy]trimethylsilane; 1-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]-pyridin-2-yl}piperazine; With acetic acid; In methanol; at 20 ℃; for 0.166667h; Molecular sieve; Inert atmosphere;

With sodium cyanoborohydride; In methanol; for 2h; Heating;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418296-67-9
1-cyclopropyl-4-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Guidance literature:: Multi-step reaction with 11 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran; ethyl acetate / 3 h / 0 - 5 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 20 °C

9.1: potassium tert-butylate / tetrahydrofuran / 22 h / Reflux

10.1: 150 °C / Inert atmosphere

11.1: acetic acid / methanol / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

11.2: 2 h / Heating

With hydrogenchloride; potassium tert-butylate; toluene-4-sulfonic acid; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418296-67-9
1-cyclopropyl-4-{4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran; ethyl acetate / 3 h / 0 - 5 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 20 °C

8.1: potassium tert-butylate / tetrahydrofuran / 22 h / Reflux

9.1: 150 °C / Inert atmosphere

10.1: acetic acid / methanol / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

10.2: 2 h / Heating

With hydrogenchloride; potassium tert-butylate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;