4-(3-hydroxy-2-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(3-hydroxy-2-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
• CAS No.: 915135-21-6
• Molecular Formula: C₁₅H₂₁N₃O₅
• Molecular Weight: 323.349
• Mol file: 915135-21-6.mol

Synonyms:4-(3-hydroxy-2-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(3-hydroxy-2-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

More than 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-hydroxy-2-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-(3-hydroxy-2-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl 4-(3-fluoro-2-nitrophenyl)piperazine-1-carboxylate (915135-20-5) → 4-(3-hydroxy-2-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (915135-21-6)

Guidance literature:

With 2-(methylsulfonyl)ethyl alcohol; sodium hydride; In N,N-dimethyl-formamide; oil; at 0 - 20 ℃; for 2.5h;

Reference yield:

4-(3-hydroxy-2-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (915135-21-6) → C15H23N3O3 (915135-23-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In isopropyl alcohol; at 20 ℃; for 18h;

upstream raw materials:

tert-butyl 4-(3-fluoro-2-nitrophenyl)piperazine-1-carboxylate

Downstream raw materials:

C₁₅H₂₃N₃O₃