(2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]-propionic acid

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Chemical Name:(2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]-propionic acid
CAS No.:334792-62-0
Molecular Formula:C₂₅H₂₇FN₆O₅S
Molecular Weight:542.591
Hs Code.:

Synonyms:(2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]-propionic acid

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Chemical Property of (2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]-propionic acid

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Technology Process of (2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]-propionic acid

There total 10 articles about (2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 334792-61-9
tert-butyl (2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

: 334792-62-0
(2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]-propionic acid

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2006.01.062

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 334792-62-0
(2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 4.6 percent / cesium carbonate; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / palladium(II) acetate / toluene / 7 h / 90 - 100 °C

2: triethylamine / CH₂Cl₂ / 0.17 h / 20 °C

3: sodium azide / dimethylformamide / 14 h / 80 °C

4: 54 mg / hydrogen / Pd/C / dioxane; H₂O / 10 h / 20 °C

5: 51 percent / ethyldiisopropylamine / dimethylsulfoxide / 6 h / 120 °C

6: 91 percent / NaOH / methanol; tetrahydrofuran; H₂O / 16 h / 45 °C

7: 100 percent / benzotriazol-1-yloxytri(dimethylamino)phosphonium PF₆; ethyldiisopropylamine / dimethylformamide; CH₂Cl₂ / 16 h / 20 °C

8: anisole; trifluoroacetic acid / CH₂Cl₂ / 8 h / 20 °C

With sodium hydroxide; sodium azide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; methoxybenzene; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2006.01.062

Reference yield:

: 334792-52-8
methyl 3-bromo-5-fluoro-benzoate

: 334792-62-0
(2S)-benzenesulfonylamino-3-[5-fluoro-3-{4-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 4.6 percent / cesium carbonate; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl / palladium(II) acetate / toluene / 7 h / 90 - 100 °C

2: triethylamine / CH₂Cl₂ / 0.17 h / 20 °C

3: sodium azide / dimethylformamide / 14 h / 80 °C

4: 54 mg / hydrogen / Pd/C / dioxane; H₂O / 10 h / 20 °C

5: 51 percent / ethyldiisopropylamine / dimethylsulfoxide / 6 h / 120 °C

6: 91 percent / NaOH / methanol; tetrahydrofuran; H₂O / 16 h / 45 °C

7: 100 percent / benzotriazol-1-yloxytri(dimethylamino)phosphonium PF₆; ethyldiisopropylamine / dimethylformamide; CH₂Cl₂ / 16 h / 20 °C

8: anisole; trifluoroacetic acid / CH₂Cl₂ / 8 h / 20 °C

With sodium hydroxide; sodium azide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; methoxybenzene; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2006.01.062