1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole

Base Information

Chemical Name:1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole
CAS No.:1416718-05-2
Molecular Formula:C₄₂H₃₇N₃O₅
Molecular Weight:663.773
Hs Code.:

Synonyms:1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole

There total 8 articles about 1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1416718-01-8
1-(2′-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1416718-05-2
1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole

Guidance literature:: With dmap; In pyridine; at 20 ℃; for 16h;
DOI:10.1021/jo302033f

Reference yield:

: 452-51-7,13046-70-3,29780-54-9,36792-87-7,36792-88-8,113890-35-0,113890-38-3
D-2-deoxyribose

: 1416718-05-2
1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / water / 20 °C

2: dmap; pyridine / 12 h / 0 °C

3: hydrogenchloride / diethyl ether / 0 °C

4: boron trifluoride diethyl etherate; trimethylsilylazide / dichloromethane / 0 °C

5: sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; copper(II) sulfate / tetrahydrofuran; water / 75 - 80 °C / Inert atmosphere

6: sodium methylate / methanol / 20 °C

7: dmap / pyridine / 16 h / 20 °C

With pyridine; hydrogenchloride; dmap; trimethylsilylazide; boron trifluoride diethyl etherate; sodium methylate; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jo302033f

Reference yield:

: 32870-97-6
3-Ethynylphenanthrene

: 1416718-05-2
1-(5′-O-(4,4′-dimethoxytrityl)-2-deoxy-β-D-ribofuranosyl)-4-(phenanthren-9-yl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; copper(II) sulfate / tetrahydrofuran; water / 75 - 80 °C / Inert atmosphere

2: sodium methylate / methanol / 20 °C

3: dmap / pyridine / 16 h / 20 °C

With dmap; sodium methylate; copper(II) sulfate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; methanol; water;
DOI:10.1021/jo302033f