trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate

Base Information

Chemical Name:trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate
CAS No.:1346762-55-7
Molecular Formula:C₄₃H₆₃N₃O₆S₂Si
Molecular Weight:810.207
Hs Code.:

trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate

Synonyms:trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate

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Chemical Property of trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate

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Technology Process of trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate

There total 6 articles about trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 743461-21-4
5-((1R)-2-amino-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-8-hydroxyquinolin-2(1H)-one

: 1346762-54-6
trans-4-[(9-bromononyl)(methyl)amino]cyclohexyl hydroxy(di-2-thienyl)acetate

: 1346762-55-7
trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate

Guidance literature:: With sodium hydrogencarbonate; at 60 ℃;

Reference yield:

: 111300-06-2
trans-tert-butyl 4-hydroxycyclohexylcarbamate

: 1346762-55-7
trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

2: acetonitrile / 20 °C

3: sodium hydride / toluene; mineral oil / 155 °C

4: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

5: triethylamine / 94 h / 70 °C / Inert atmosphere

6: sodium hydrogencarbonate / 60 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile; mineral oil;

Reference yield:

: 22348-44-3
trans-4-Methylamino-cyclohexanol

: 1346762-55-7
trans-4-[(9-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}nonyl)(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / 20 °C

2: sodium hydride / toluene; mineral oil / 155 °C

3: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

4: triethylamine / 94 h / 70 °C / Inert atmosphere

5: sodium hydrogencarbonate / 60 °C

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; toluene; acetonitrile; mineral oil;