ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate

Base Information

Chemical Name:ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate
CAS No.:929693-91-4
Molecular Formula:C₂₅H₂₈N₂O₇S₂
Molecular Weight:532.639
Hs Code.:

Synonyms:ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate

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Chemical Property of ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate

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Technology Process of ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate

There total 7 articles about ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 929693-90-3
4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazole-5-carboxylic acid

: 55458-83-8
ethyl 2-{[4-(aminomethyl)phenyl]oxy}-2-methylpropanoate

: 929693-91-4
ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm058056x

Reference yield:

: 600-00-0
ethyl 2-bromoisobutyrate

: 929693-91-4
ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: dimethylformamide / 20 - 80 °C

2.1: H₂; AcOH / Pd/C / ethanol / 8 h / 20 °C / 1500.12 Torr

3.1: 73 percent / HOBT; EDCI; Et₃N / dimethylformamide / 20 °C

With hydrogen; sodium hydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm058056x

Reference yield:

: 18672-07-6
2-(4-cyanophenoxy)-2-methylpropionic acid ethyl ester

: 929693-91-4
ethyl 2-methyl-2-{[4-({[(4-methyl-2-{4-[(methylsulfonyl)oxy]phenyl}-1,3-thiazol-5-yl)carbonyl]amino}methyl)phenyl]oxy}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂; AcOH / Pd/C / ethanol / 8 h / 20 °C / 1500.12 Torr

2: 73 percent / HOBT; EDCI; Et₃N / dimethylformamide / 20 °C

With hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm058056x