6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester
CAS No.:164148-49-6
Molecular Formula:C₃₄H₄₆N₄O₈
Molecular Weight:638.761
Hs Code.:

6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester

Synonyms:6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester

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Chemical Property of 6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester

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Technology Process of 6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester

There total 9 articles about 6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22245-98-3
6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one

: 164148-49-6
6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / K₂CO₃ / acetone / 16 h / Heating

2: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, RT, 1 h

3: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 1.5 h

4: K₂CO₃ / acetone / 12 h / Heating

5: 85percent aq. N₂H₄ / ethanol / 1 h / 65 °C

6: CH₂Cl₂ / 96 h / Ambient temperature

With hydrogen; sodium hydride; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm9701076

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 164148-49-6
6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, RT, 1 h

2: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 1.5 h

3: K₂CO₃ / acetone / 12 h / Heating

4: 85percent aq. N₂H₄ / ethanol / 1 h / 65 °C

5: CH₂Cl₂ / 96 h / Ambient temperature

With hydrogen; sodium hydride; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm9701076

Reference yield:

: 164147-66-4
6-(benzyloxy)-3,4-dihydroisoquinolin-1(2H)-one

: 164148-49-6
6-{[4-({[N,N'-bis[(1,1-dimethylethoxy)carbonyl]aminoiminomethyl]amino}methyl)phenyl]methoxy}-3,4-dihydro-1-oxo-2(1H)-isoquinolineacetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, RT, 1 h

2: 95 percent / H₂ / 10percent Pd/C / ethyl acetate / 1.5 h

3: K₂CO₃ / acetone / 12 h / Heating

4: 85percent aq. N₂H₄ / ethanol / 1 h / 65 °C

5: CH₂Cl₂ / 96 h / Ambient temperature

With hydrogen; sodium hydride; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm9701076