N-(4-(2-methyl-4-pyridinyl)phenyl)-2-(3-(4-(2-pyridinyl)-1-piperazinyl)phenyl)-propanamide

Base Information

Chemical Name:N-(4-(2-methyl-4-pyridinyl)phenyl)-2-(3-(4-(2-pyridinyl)-1-piperazinyl)phenyl)-propanamide
CAS No.:1161356-62-2
Molecular Formula:C₃₀H₃₁N₅O
Molecular Weight:477.609
Hs Code.:

Synonyms:N-(4-(2-methyl-4-pyridinyl)phenyl)-2-(3-(4-(2-pyridinyl)-1-piperazinyl)phenyl)-propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(2-methyl-4-pyridinyl)phenyl)-2-(3-(4-(2-pyridinyl)-1-piperazinyl)phenyl)-propanamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(4-(2-methyl-4-pyridinyl)phenyl)-2-(3-(4-(2-pyridinyl)-1-piperazinyl)phenyl)-propanamide

There total 7 articles about N-(4-(2-methyl-4-pyridinyl)phenyl)-2-(3-(4-(2-pyridinyl)-1-piperazinyl)phenyl)-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53086-52-5
2-(3-bromophenyl)-propionic acid

: 1161356-62-2
N-(4-(2-methyl-4-pyridinyl)phenyl)-2-(3-(4-(2-pyridinyl)-1-piperazinyl)phenyl)-propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h

3: potassium dihydrogenphosphate; (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine / water; 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

With potassium dihydrogenphosphate; oxalyl dichloride; (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2013.09.041

Reference yield:

: C₉H₁₄BN₃O₂

: 2-(3-bromophenyl)-N-(4-(2-methylpyridin-4-yl)phenyl)propanamide

: 1161356-62-2
N-(4-(2-methyl-4-pyridinyl)phenyl)-2-(3-(4-(2-pyridinyl)-1-piperazinyl)phenyl)-propanamide

Guidance literature:: With potassium dihydrogenphosphate; (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.bmcl.2013.09.041

Reference yield:

: 216059-91-5
4-(2-methylpyridin-4-yl)phenylamine

: 1161356-62-2
N-(4-(2-methyl-4-pyridinyl)phenyl)-2-(3-(4-(2-pyridinyl)-1-piperazinyl)phenyl)-propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h

2: potassium dihydrogenphosphate; (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine / water; 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

With potassium dihydrogenphosphate; (4-(N,N-dimethylamino)phenyl)-di-tert-butylphosphine; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmcl.2013.09.041