Technology Process of 4-((2-(9H-pyrido[3,4-b]indole-3-carbonyl)amino)methyl)benzoic acid methyl ester
There total 8 articles about 4-((2-(9H-pyrido[3,4-b]indole-3-carbonyl)amino)methyl)benzoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-amino-9H-β-carboline; methyl 4-formylbenzoate;
With
acetic acid;
In
methanol;
at 20 ℃;
for 1.5h;
Inert atmosphere;
With
sodium cyanoborohydride;
In
methanol;
at 20 ℃;
for 12h;
Further stages;
DOI:10.1016/j.ejmech.2010.11.044
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trichloroisocyanuric acid; triethylamine / N,N-dimethyl-formamide / 2 h / -20 - 0 °C
2.1: hydrazine hydrate / pentan-1-ol / 7 h / 150 °C
3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C
4.1: o-xylene / 1 h / 160 °C
5.1: water; potassium hydroxide / ethanol / 2 h / Reflux
6.1: acetic acid / methanol / 1.5 h / 20 °C / Inert atmosphere
6.2: 12 h / 20 °C
With
hydrogenchloride; trichloroisocyanuric acid; water; hydrazine hydrate; acetic acid; triethylamine; potassium hydroxide; sodium nitrite;
In
methanol; ethanol; pentan-1-ol; o-xylene; water; N,N-dimethyl-formamide;
4.1: Curtius rearrangement;
DOI:10.1016/j.ejmech.2010.11.044
