(2S)-5'-Benzyloxycarbonyl-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalaninmethylester

Base Information

Chemical Name:(2S)-5'-Benzyloxycarbonyl-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalaninmethylester
CAS No.:91421-14-6
Molecular Formula:C₂₅H₃₁NO₇
Molecular Weight:457.524
Hs Code.:

Synonyms:(2S)-5'-Benzyloxycarbonyl-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalaninmethylester

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Chemical Property of (2S)-5'-Benzyloxycarbonyl-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalaninmethylester

Chemical Property:

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Technology Process of (2S)-5'-Benzyloxycarbonyl-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalaninmethylester

There total 5 articles about (2S)-5'-Benzyloxycarbonyl-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalaninmethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91420-99-4
3-formyl-4-methoxy-benzoic acid

: 91421-14-6
(2S)-5'-Benzyloxycarbonyl-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalaninmethylester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1N NaOH / 2.) DMF, 4 h, 70 deg C

2: 72 percent / t-BuOK / CH₂Cl₂ / 1.) <= -60 deg C, 2.) room temperature, 3 h

3: 78 percent / K₂CO₃ / dimethylformamide / 72 h

4: 97 percent / H₂ / >-tetrafluoroborate / ethanol / 18 h / 40 °C / 2206.5 Torr

With sodium hydroxide; potassium tert-butylate; hydrogen; potassium carbonate; >-tetrafluoroborate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840616

Reference yield:

: 121056-95-9,89524-98-1
trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

: 91421-14-6
(2S)-5'-Benzyloxycarbonyl-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalaninmethylester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / t-BuOK / CH₂Cl₂ / 1.) <= -60 deg C, 2.) room temperature, 3 h

2: 78 percent / K₂CO₃ / dimethylformamide / 72 h

3: 97 percent / H₂ / >-tetrafluoroborate / ethanol / 18 h / 40 °C / 2206.5 Torr

With potassium tert-butylate; hydrogen; potassium carbonate; >-tetrafluoroborate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840616

Reference yield:

: 100-44-7
benzyl chloride

: 91421-14-6
(2S)-5'-Benzyloxycarbonyl-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalaninmethylester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1N NaOH / 2.) DMF, 4 h, 70 deg C

2: 72 percent / t-BuOK / CH₂Cl₂ / 1.) <= -60 deg C, 2.) room temperature, 3 h

3: 78 percent / K₂CO₃ / dimethylformamide / 72 h

4: 97 percent / H₂ / >-tetrafluoroborate / ethanol / 18 h / 40 °C / 2206.5 Torr

With sodium hydroxide; potassium tert-butylate; hydrogen; potassium carbonate; >-tetrafluoroborate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840616