Technology Process of tert-butyl (3R)-3-(3,5-difluorophenyl)-3-methyl-5-oxo-1,4-diazaspiro[5.5]undecane-1-carboxylate
There total 8 articles about tert-butyl (3R)-3-(3,5-difluorophenyl)-3-methyl-5-oxo-1,4-diazaspiro[5.5]undecane-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
at 60 ℃;
for 8h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: ammonia / titanium(IV) isopropylate / ethanol / 20 h / 20 °C
1.2: 2 h / Cooling
2.1: dichloromethane / 0 - 20 °C
2.2: 60 - 70 °C
3.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C
3.2: -78 - 0 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C
5.1: acetic acid / methanol / 0.5 h / 20 °C
5.2: 1 h / 20 °C / pH 5
6.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C
7.1: acetic acid / xylenes / 3 h / 80 °C
8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 8 h / 60 °C
With
hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; ammonia; acetic acid; N-ethyl-N,N-diisopropylamine;
titanium(IV) isopropylate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; acetonitrile; xylenes;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: dichloromethane / 0 - 20 °C
1.2: 60 - 70 °C
2.1: potassium tert-butylate / tetrahydrofuran / -78 - 20 °C
2.2: -78 - 0 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C
4.1: acetic acid / methanol / 0.5 h / 20 °C
4.2: 1 h / 20 °C / pH 5
5.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C
6.1: acetic acid / xylenes / 3 h / 80 °C
7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 8 h / 60 °C
With
hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile; xylenes;