(1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole

Base Information

Chemical Name:(1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole
CAS No.:647028-68-0
Molecular Formula:C₄₃H₅₆N₂O₃Si₂
Molecular Weight:705.1
Hs Code.:

(1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole

Synonyms:(1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole

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Chemical Property of (1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole

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Technology Process of (1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole

There total 1 articles about (1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 647028-66-8
(2S,3R)-2-[5-[3,6-bis-(tert-butyldimethylsilyloxy)-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine

: 647028-68-0
(1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole

Guidance literature:: (2S,3R)-2-[5-[3,6-bis-(tert-butyldimethylsilyloxy)-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine; With silver trifluoromethanesulfonate; In acetonitrile; at 70 ℃; for 3h;

With benzyltrimethylammonium cyanide; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1021/ja030452m

Reference yield:

: 647028-68-0
(1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole

: 647028-71-5
C₃₁H₂₈N₂O₃

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ja030452m

Reference yield:

: 647028-68-0
(1S,2S)-8-tert-butyldimethylsilyloxy-9-tert-butyldimethylsilyloxymethyl-2,3,5,6,7,8-hexahydro-5-oxo-1,2-(N-tritylaziridino)-1H-pyrrolo[1,2-a]indole

: 647028-72-6
C₃₂H₂₉N₃O₄

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: CH₂Cl₂ / 1 h / -78 °C

3: aq. K₂CO₃; MeOH / 5 h / 20 °C

With methanol; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja030452m