methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate

Base Information

• Chemical Name: methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate
• CAS No.: 1364122-00-8
• Molecular Formula: C₁₅H₁₈O₄
• Molecular Weight: 262.306
• Mol file: 1364122-00-8.mol

Synonyms:methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate

Chemical Property of methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate

There total 9 articles about methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + methyl 4-formylbenzoate (1571-08-0) → (S)-2-((R)-hydroxy(4-methoxycarbonylphenyl)methyl)cyclohexan-1-one + methyl 4‐((S)‐hydroxy((R)-2-oxocyclohexyl)methyl)benzoate + methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate (1364122-00-8)

Guidance literature:

With (S)-N-(2-(diphenylphosphino)phenyl)methylpyrrolidine-2-carboxyamide; trifluoroacetic acid; In N,N-dimethyl-formamide; at 0 ℃; for 48h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetasy.2011.11.021

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + methyl 4-formylbenzoate (1571-08-0) → methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate (1364122-00-8) + methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate + methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate

Guidance literature:

With gold nanoparticle-supported O-(11-sulfanylundecanoyl)-trans-4-hydroxy-L-proline; In water; dimethyl sulfoxide; at 25 ℃; for 72h; Overall yield = 99 %; Overall yield = 15.6 mg; stereoselective reaction;

DOI:10.1016/j.tet.2016.02.065

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + methyl 4-formylbenzoate (1571-08-0) → (S)-2-((R)-hydroxy(4-methoxycarbonylphenyl)methyl)cyclohexan-1-one + methyl 4-(hydroxy(2-oxocyclohexyl)methyl)benzoate (1364122-00-8)

Guidance literature:

With polystyrene-supported threonine-derived organocatalyst; In water; N,N-dimethyl-formamide; at 20 ℃; for 16h; Overall yield = 81 %; enantioselective reaction;

DOI:10.1002/adsc.201400033

upstream raw materials:

cyclohexanone

methyl 4-formylbenzoate

4-(methoxycarbonyl)benzyl alcohol

Refernces

• 1、 Sóti, Péter Lajos,Yamashita, Hiroki,Sato, Kohei,Narumi, Tetsuo,Toda, Mitsuo,Watanabe, Naoharu,Marosi, Gy?rgy,Mase, Nobuyuki. "Synthesis of a self-assembling gold nanoparticle-supported organocatalyst for enamine-based asymmetric aldol reactions". . p. 1984 - 1990. Retrieved 2016.
• 2、 Fanjul-Mosteirín, Noé,Concellón, Carmen,Del Amo, Vicente. "L-isoleucine in a choline chloride/ethylene glycol deep eutectic solvent: A reusable reaction kit for the asymmetric cross-aldol carboligation". supporting information. p. 4266 - 4269. Retrieved 2016/09/09.