benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate

Base Information

Chemical Name:benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate
CAS No.:160032-80-4
Molecular Formula:C₂₅H₂₁NO₆S
Molecular Weight:464.503
Hs Code.:

Synonyms:benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate

Chemical Property:

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Technology Process of benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate

There total 4 articles about benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27266-61-1,54600-89-4
benzhydryl 7-aminocephalosporanate

: 160032-80-4
benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N, 2.) Tf₂O, 3.) HCl

2: tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -40 deg C, 1.5 h

With hydrogenchloride; trifluoromethylsulfonic anhydride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja00103a010

Reference yield:

: 957-68-6
7-Aminocephalosporanic acid

: 160032-80-4
benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / methanol; CH₂Cl₂ / 44 h / Ambient temperature

2: 1.) Et₃N, 2.) Tf₂O, 3.) HCl

3: tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -40 deg C, 1.5 h

With hydrogenchloride; trifluoromethylsulfonic anhydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00103a010

Reference yield:

: 908093-98-1
diazodiphenylmethane

: 160032-80-4
benzhydryl 7α-(2'-deuterioethynyl)-7β-hydroxycephalosporanate

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / methanol; CH₂Cl₂ / 44 h / Ambient temperature

2: 1.) Et₃N, 2.) Tf₂O, 3.) HCl

3: tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -40 deg C, 1.5 h

With hydrogenchloride; trifluoromethylsulfonic anhydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00103a010