N-(benzyloxycarbonyl)-O-benzyl-N-<2-(aminomethylene)malonyl>-L-phenylalanine methyl ester

Base Information

Chemical Name:N-(benzyloxycarbonyl)-O-benzyl-N-<2-(aminomethylene)malonyl>-L-phenylalanine methyl ester
CAS No.:72594-85-5
Molecular Formula:C₂₉H₃₀N₂O₇
Molecular Weight:518.566
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-O-benzyl-N-<2-(aminomethylene)malonyl>-L-phenylalanine methyl ester

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Chemical Property of N-(benzyloxycarbonyl)-O-benzyl-N-<2-(aminomethylene)malonyl>-L-phenylalanine methyl ester

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Technology Process of N-(benzyloxycarbonyl)-O-benzyl-N-<2-(aminomethylene)malonyl>-L-phenylalanine methyl ester

There total 5 articles about N-(benzyloxycarbonyl)-O-benzyl-N-<2-(aminomethylene)malonyl>-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 72594-88-8
N-(benzyloxycarbonyl)-2-(aminomethylene)malonic acid benzyl ester

: 72594-85-5
N-(benzyloxycarbonyl)-O-benzyl-N-<2-(aminomethylene)malonyl>-L-phenylalanine methyl ester

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; for 48h; Ambient temperature;
DOI:10.1021/jm00178a012

Reference yield:

: 31037-42-0
hydroxymethyl carbamic acid benzyl ester

: 72594-85-5
N-(benzyloxycarbonyl)-O-benzyl-N-<2-(aminomethylene)malonyl>-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / Et₃N / tetrahydrofuran / 4 h / Ambient temperature

2: 1.) NaH / 1.) THF, 15 min, 2.) THF, 2 h

3: 99 percent / CF₃CO₂H / 2 h / Ambient temperature

4: 72 percent / Et₃N, dicyclohexylcarbodiimide / CH₂Cl₂ / 48 h / Ambient temperature

With sodium hydride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00178a012

Reference yield:

: 67799-92-2
benzyloxycarbonylaminomethyl acetate

: 72594-85-5
N-(benzyloxycarbonyl)-O-benzyl-N-<2-(aminomethylene)malonyl>-L-phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, 15 min, 2.) THF, 2 h

2: 99 percent / CF₃CO₂H / 2 h / Ambient temperature

3: 72 percent / Et₃N, dicyclohexylcarbodiimide / CH₂Cl₂ / 48 h / Ambient temperature

With sodium hydride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00178a012