(S)-1-benzyl-2-isopropyl-pyrrolidine

Base Information

Chemical Name:(S)-1-benzyl-2-isopropyl-pyrrolidine
CAS No.:615268-24-1
Molecular Formula:C₁₄H₂₁N
Molecular Weight:203.327
Hs Code.:

Synonyms:(S)-1-benzyl-2-isopropyl-pyrrolidine

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Chemical Property of (S)-1-benzyl-2-isopropyl-pyrrolidine

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Technology Process of (S)-1-benzyl-2-isopropyl-pyrrolidine

There total 7 articles about (S)-1-benzyl-2-isopropyl-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 213772-31-7
4-[N-benzyl-N-(tert-butyloxycarbonyl)]-amino-1-butanal

: 615268-24-1
(S)-1-benzyl-2-isopropyl-pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / potassium tert-butoxide / acetonitrile; 2-methyl-propan-2-ol

2: 88 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.33 h / cooling

With oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; triethylamine; In dichloromethane; acetonitrile; tert-butyl alcohol; 1: Henry reaction / 2: Swern oxidation;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 477952-40-2
6-[N-benzyl-N-(tert-butyloxycarbonyl)]amino-3-hydroxy-2-methyl-2-nitrohexane

: 615268-24-1
(S)-1-benzyl-2-isopropyl-pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.33 h / cooling

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; 1: Swern oxidation;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 477952-41-3
6-[N-benzyl-N-(tert-butyloxycarbonyl)]amino-2-methyl-2-nitro-2-hexanone

: 615268-24-1
(S)-1-benzyl-2-isopropyl-pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: (S)-(-)-α,α-diphenyl-2-pyrrolidinemethanol; BH3*SMe2 / tetrahydrofuran / 0.33 h / 45 - 50 °C

2: 98 percent / DMAP / CH₂Cl₂ / 20 °C

3: 99 percent / TFA / CH₂Cl₂ / 20 °C

4: AIBN; tributyltin hydride / benzene / 30 h / Heating

With dmap; 2,2'-azobis(isobutyronitrile); (S)-diphenylprolinol; dimethylsulfide borane complex; tri-n-butyl-tin hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ol035564x