ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate

Base Information

Chemical Name:ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate
CAS No.:727417-39-2
Molecular Formula:C₂HF₃O₂*C₂₃H₂₆BrClN₆O₆
Molecular Weight:711.877
Hs Code.:

ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate

Synonyms:ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate

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Chemical Property of ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate

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Technology Process of ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate

There total 1 articles about ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247102-01-8
5-N-(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)-5-amino-nicotinic acid

: ethyl (3R)-3-(N-Gly)amino-3-(3-bromo-5-chloro-2-hydroxyphenyl)propanoate hydrochloride

: 727417-39-2
ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate

Guidance literature:: 5-N-(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)-5-amino-nicotinic acid; With 4-methyl-morpholine; isobutyl chloroformate; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.333333h;

ethyl (3R)-3-(N-Gly)amino-3-(3-bromo-5-chloro-2-hydroxyphenyl)propanoate hydrochloride; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃;

Reference yield:

: 727417-39-2
ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate

: 76-05-1
trifluoroacetic acid

: 727417-35-8
(3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoic acid monotrifluoroacetate

Guidance literature:: ethyl (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}propanoate monotrifluoroacetate; With sodium hydroxide; water; at 20 ℃; for 4h;

trifluoroacetic acid; pH=4;