1-{4-[(4-acetyl-3-hydroxy-2-ethylphenyl)methoxy]phenyl}-3,3-dimethyl-4-(1H-tetrazol-5-yl)-1-butanone

Base Information

Chemical Name:1-{4-[(4-acetyl-3-hydroxy-2-ethylphenyl)methoxy]phenyl}-3,3-dimethyl-4-(1H-tetrazol-5-yl)-1-butanone
CAS No.:119348-47-9
Molecular Formula:C₂₄H₂₈N₄O₄
Molecular Weight:436.511
Hs Code.:

Synonyms:1-{4-[(4-acetyl-3-hydroxy-2-ethylphenyl)methoxy]phenyl}-3,3-dimethyl-4-(1H-tetrazol-5-yl)-1-butanone

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Chemical Property of 1-{4-[(4-acetyl-3-hydroxy-2-ethylphenyl)methoxy]phenyl}-3,3-dimethyl-4-(1H-tetrazol-5-yl)-1-butanone

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Technology Process of 1-{4-[(4-acetyl-3-hydroxy-2-ethylphenyl)methoxy]phenyl}-3,3-dimethyl-4-(1H-tetrazol-5-yl)-1-butanone

There total 9 articles about 1-{4-[(4-acetyl-3-hydroxy-2-ethylphenyl)methoxy]phenyl}-3,3-dimethyl-4-(1H-tetrazol-5-yl)-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 119348-32-2
5-[4-(4-Acetyl-2-ethyl-3-hydroxy-benzyloxy)-phenyl]-3,3-dimethyl-5-oxo-pentanenitrile

: 119348-47-9
1-{4-[(4-acetyl-3-hydroxy-2-ethylphenyl)methoxy]phenyl}-3,3-dimethyl-4-(1H-tetrazol-5-yl)-1-butanone

Guidance literature:: With tributyltin azide; In monoethylene glycol diethyl ether; for 96h; Heating;
DOI:10.1021/jm00113a014

Reference yield: 41.0%

: 119348-47-9
1-{4-[(4-acetyl-3-hydroxy-2-ethylphenyl)methoxy]phenyl}-3,3-dimethyl-4-(1H-tetrazol-5-yl)-1-butanone

Guidance literature:

Reference yield:

: 4160-82-1
3,3-dimethylglutaric anhydride

: 119348-47-9
1-{4-[(4-acetyl-3-hydroxy-2-ethylphenyl)methoxy]phenyl}-3,3-dimethyl-4-(1H-tetrazol-5-yl)-1-butanone

Guidance literature:: Multi-step reaction with 7 steps

1: aluminum chloride / CH₂Cl₂ / 3 h

2: methanesulfonyl chloride, pyridine / 1 h / 0 °C

3: NH₃(gas) / Ambient temperature

4: methanesulfonyl chloride / 2 h / 0 - 20 °C

5: 76 percent / aluminum chloride / CH₂Cl₂ / 20 h / Heating

6: 65 percent / potassium-t-butoxide, NaI / ethanol / 30 h / Ambient temperature

7: 78 percent / tributyltin azide / 1,2-diethoxy-ethane / 96 h / Heating

With pyridine; aluminium trichloride; tributyltin azide; potassium tert-butylate; ammonia; methanesulfonyl chloride; sodium iodide; In ethanol; dichloromethane; monoethylene glycol diethyl ether;
DOI:10.1021/jm00113a014