(S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethyl oxime

Base Information

Chemical Name:(S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethyl oxime
CAS No.:1433608-09-3
Molecular Formula:C₂₇H₃₀FN₅O₃
Molecular Weight:491.565
Hs Code.:

Synonyms:(S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethyl oxime

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Chemical Property of (S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethyl oxime

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Technology Process of (S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethyl oxime

There total 4 articles about (S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17739-45-6,59146-56-4
2-(2-bromoethoxy)tetrahydropyran

: 1313379-34-8
(S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

: 1433608-09-3
(S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethyl oxime

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1433605-21-0
(E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

: 1433608-09-3
(S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethyl oxime

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: butan-1-ol / tetrahydrofuran / 36 h / 30 °C / Enzymatic reaction

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

With sodium hydride; triethylamine; butan-1-ol; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: (E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-acetyl oxime

: 1433608-09-3
(S,E)-2-amino-7-(4-fluoro-2-(pyridin-3-yl)phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-(tetrahydro-2H-pyran-2-yl)oxy)ethyl oxime

Guidance literature:: Multi-step reaction with 2 steps

1: butan-1-ol / tetrahydrofuran / 36 h / 30 °C / Enzymatic reaction

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C / Inert atmosphere

With sodium hydride; butan-1-ol; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;