Diphenyl-carbamic acid 6-amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl ester

Base Information

• Chemical Name: Diphenyl-carbamic acid 6-amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl ester
• CAS No.: 187664-10-4
• Molecular Formula: C₂₃H₂₂N₆O₅
• Molecular Weight: 462.465
• Mol file: 187664-10-4.mol

Synonyms:Diphenyl-carbamic acid 6-amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl ester

Chemical Property of Diphenyl-carbamic acid 6-amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diphenyl-carbamic acid 6-amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl ester

There total 1 articles about Diphenyl-carbamic acid 6-amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

diphenylcarbamic chloride (83-01-2) + 2'-deoxyisoguanosine (106449-56-3) → Diphenyl-carbamic acid 6-amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl ester (187664-10-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In pyridine; for 5.5h; Ambient temperature;

DOI:10.1002/hlca.19970800107

Reference yield:

Diphenyl-carbamic acid 6-amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl ester (187664-10-4) → Diphenyl-carbamic acid 6-amino-9H-purin-2-yl ester

Guidance literature:

With hydrogenchloride; In water; at 25 ℃; Rate constant; Product distribution; half-life time 125 min; stability of glycosylic bond;

DOI:10.1002/hlca.19970800107

Reference yield:

Diphenyl-carbamic acid 6-amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl ester (187664-10-4) → Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-isobutyrylamino-9H-purin-2-yl ester

Guidance literature:

Multi-step reaction with 2 steps

1: Me₃SiCl

With chloro-trimethyl-silane;

DOI:10.1080/07328319708006221

upstream raw materials:

diphenylcarbamic chloride

2'-deoxyisoguanosine