GSK2190915 (sodiuM salt)

Base Information

• Chemical Name: GSK2190915 (sodiuM salt)
• CAS No.: 1196070-26-4
• Molecular Formula: C₃₈H₄₂N₃O₄S*Na
• Molecular Weight: 659.825

Synonyms:3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid sodium salt

Chemical Property of GSK2190915 (sodiuM salt)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

GSK2190915sodiumsalt 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of GSK2190915 (sodiuM salt)

There total 9 articles about GSK2190915 (sodiuM salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (936350-00-4) → 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid sodium salt (1196070-26-4)

Guidance literature:

With sodium hydroxide; In ethanol; at 72 ℃; for 0.416667h; Product distribution / selectivity; Industry scale;

Reference yield:

3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester (1196965-16-8) → 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid sodium salt (1196070-26-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; at 66 - 75 ℃; for 17.5h; Industry scale;

Reference yield:

p-hydroxymethylphenylboronic acid (59016-93-2) → 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid sodium salt (1196070-26-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium carbonate / palladium 10% on activated carbon / ethanol; water / 5 h / 63 °C / Industry scale; Inert atmosphere; Reflux

2.1: hydrogen bromide; acetic acid / 4 h / 45 - 55 °C / Industry scale

3.1: hydrogenchloride; sodium nitrite / water / 0 - 5 °C

3.2: 0.17 h / 10 - 25 °C / pH 7 / Inert atmosphere

3.3: 18 °C

4.1: citric acid; rac-tartaric acid dibenzoate / 2-methyltetrahydrofuran / 21 h / 30 - 55 °C / Industry scale; Inert atmosphere

4.2: 1 h / Industry scale

4.3: Industry scale

5.1: sodium hydroxide / ethanol / 0.42 h / 72 °C / Industry scale

With hydrogenchloride; rac-tartaric acid dibenzoate; hydrogen bromide; sodium carbonate; acetic acid; citric acid; sodium hydroxide; sodium nitrite; palladium 10% on activated carbon; In 2-methyltetrahydrofuran; ethanol; water;

upstream raw materials:

3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester

p-hydroxymethylphenylboronic acid

5-bromo-2-ethoxypyridine

3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid

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