2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid

Base Information

Chemical Name:2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid
CAS No.:152608-54-3
Molecular Formula:C₃₃H₃₃FO₅S
Molecular Weight:560.686
Hs Code.:

Synonyms:2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid

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Chemical Property of 2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid

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Technology Process of 2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid

There total 14 articles about 2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 152610-23-6
2-<2-propyl-3-<3-<2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy>propoxy>thiophenoxy>benzoic acid methyl ester

: 152608-54-3
2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 1h; Ambient temperature;
DOI:10.1021/jm00022a006

Reference yield:

: 29682-12-0
1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

: 152608-54-3
2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / K₂CO₃ / dimethylsulfoxide; butan-2-one / 24 h / Heating

2: 69 percent / trifluoroacetic acid, triethylsilane / CCl₄ / 1.5 h / Ambient temperature

3: 73 percent / N-bromosuccinimide / CCl₄ / 6 h / Ambient temperature

4: 84 percent / Pd(PPh₃)4, aq. Na₂CO₃ / ethanol; benzene / 16 h / Heating

5: 66 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

6: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

7: BBr₃ / CH₂Cl₂ / 1 h / -78 °C

8: 100 percent / aq. NaOH / methanol; tetrahydrofuran / 1 h / Ambient temperature

With triethylsilane; sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; boron tribromide; sodium carbonate; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; butanone; benzene;
DOI:10.1021/jm00022a006

Reference yield:

: 71112-91-9
bis(2-bromophenyl) disulfide

: 152608-54-3
2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-phenylsulfanyl}-benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) n-BuLi / 1.) THF, -74 deg C, 30 min, 2.) THF, from -74 deg C to RT

2: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to RT

3: HCl(g) / 18 h / Ambient temperature

4: 41 percent / 30 h / 175 °C

5: 66 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

6: H₂ / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature

7: BBr₃ / CH₂Cl₂ / 1 h / -78 °C

8: 100 percent / aq. NaOH / methanol; tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; n-butyllithium; hydrogen; boron tribromide; potassium carbonate; dimethyl sulfoxide; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; butanone;
DOI:10.1021/jm00022a006