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Technology Process of Leucinostatin A

Leucinostatin A

Base Information
  • Chemical Name:Leucinostatin A
  • CAS No.:76600-38-9
  • Deprecated CAS:82111-44-2,81859-20-3
  • Molecular Formula:C62H111N11O13
  • Molecular Weight:1218.63
  • Hs Code.:
  • NSC Number:356885
  • Metabolomics Workbench ID:97875
  • ChEMBL ID:CHEMBL1989620
Leucinostatin A

Synonyms:A 20668;leucinostatin;leucinostatin A;leucinostatin A, hydrochloride;leucinostatin A, monoacetate salt;paecilotoxin A

Suppliers and Price of Leucinostatin A
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Cayman Chemical
  • Leucinostatin A
  • 2.5mg
  • $ 774.00
  • Cayman Chemical
  • Leucinostatin A
  • 500μg
  • $ 194.00
Total 8 raw suppliers
Chemical Property of Leucinostatin A
Chemical Property:
  • Vapor Pressure:0mmHg at 25°C 
  • Boiling Point:1408°C at 760 mmHg 
  • PKA:12.66±0.46(Predicted) 
  • Flash Point:805.3°C 
  • PSA：342.98000 
  • Density:1.116g/cm3 
  • LogP:5.73340 
  • XLogP3:4.3
  • Hydrogen Bond Donor Count:11
  • Hydrogen Bond Acceptor Count:14
  • Rotatable Bond Count:37
  • Exact Mass:1217.83628264
  • Heavy Atom Count:86
  • Complexity:2340
Purity/Quality:

99.5% *data from raw suppliers

Leucinostatin A *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Canonical SMILES:CCC(C)C=CC(=O)N1CC(CC1C(=O)NC(CC(C)CC(CC(=O)CC)O)C(=O)NC(C(C(C)C)O)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NCCC(=O)NC(C)CN(C)C)C
  • Isomeric SMILES:CCC(C)/C=C/C(=O)N1CC(CC1C(=O)NC(CC(C)CC(CC(=O)CC)O)C(=O)NC(C(C(C)C)O)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NCCC(=O)NC(C)CN(C)C)C
  • Description Leucinostatin A is a fungal metabolite originally isolated from P. lilacinus with diverse biological activities. It is active against P. oryzae, B. cinera, P. chrysogenum, X. oryzae, S. cerevisiae, and C. albicans fungi and B. subtilis, S. aureus, S. lutea, and M. phlei bacteria in a disc assay. Leucinostatin A (0.1-1 μg/ml) reduces T cell activation induced by phorbol 12-myristate 13-acetate (TPA; ) or an anti-CD3 antibody in a concentration-dependent manner. It inhibits proliferation of DU145 prostate cancer cells co-cultured with PrSC stromal cells in vitro (IC50 = 0.045 μg/ml).
  • Uses Leucinostatin A is the major component of an atypical nonapeptide complex produced by Paecilomyces lilacinus, first reported in 1973. Leucinostatins display broad bioactivity against Gram positive bacteria, fungi, plants and tumour cell lines. Leucinostatin A inhibits respiration by uncoupling oxidative phosphorylation and is potentiated by inhibitors such as venturicidin and oligomycin. More recently, interest in leucinostatin has focused on understanding its activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti-trypanosomal activity. Leucinostatin A is a broadly bioactive component produced by?Paecilomyces lilacinus..
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