N-(3,5-bis(trifluoromethyl)benzyl)-1-(4-(2-fluorophenyl)pyridin-3-yl)methanamine

Base Information

• Chemical Name: N-(3,5-bis(trifluoromethyl)benzyl)-1-(4-(2-fluorophenyl)pyridin-3-yl)methanamine
• CAS No.: 1491169-02-8
• Molecular Formula: C₂₁H₁₅F₇N₂
• Molecular Weight: 428.352
• Mol file: 1491169-02-8.mol

Synonyms:N-(3,5-bis(trifluoromethyl)benzyl)-1-(4-(2-fluorophenyl)pyridin-3-yl)methanamine

Chemical Property of N-(3,5-bis(trifluoromethyl)benzyl)-1-(4-(2-fluorophenyl)pyridin-3-yl)methanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-bis(trifluoromethyl)benzyl)-1-(4-(2-fluorophenyl)pyridin-3-yl)methanamine

There total 8 articles about N-(3,5-bis(trifluoromethyl)benzyl)-1-(4-(2-fluorophenyl)pyridin-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-(2-fluorophenyl)nicotinaldehyde (1367961-67-8) + 3,5-bis-trifluoromethylbenzylamine (85068-29-7) → N-(3,5-bis(trifluoromethyl)benzyl)-1-(4-(2-fluorophenyl)pyridin-3-yl)methanamine (1491169-02-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

3,5-Bis(trifluoromethyl)benzaldehyde (401-95-6) + (4-(2-fluorophenyl)pyridin-3-yl)methanamine dihydrochloride → N-(3,5-bis(trifluoromethyl)benzyl)-1-(4-(2-fluorophenyl)pyridin-3-yl)methanamine (1491169-02-8)

Guidance literature:

With titanium(IV) isopropylate; triethylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

ethyl 4-(2-fluorophenyl)nicotinate (1491168-99-0) → N-(3,5-bis(trifluoromethyl)benzyl)-1-(4-(2-fluorophenyl)pyridin-3-yl)methanamine (1491169-02-8)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

2: [bis(acetoxy)iodo]benzene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 20 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1016/j.ejmech.2013.07.050

upstream raw materials:

3,5-Bis(trifluoromethyl)benzaldehyde

ethyl 4-(2-fluorophenyl)nicotinate

o-fluorophenylboronic acid

(4-(2-fluorophenyl)pyridin-3-yl)methanamine

Downstream raw materials:

2-(3,5-bis(trifluoromethyl)phenyl)-2-((4-(2-fluorophenyl)pyridin-3-yl)methylamino)acetonitrile

2-(3,5-bis(trifluoromethyl)phenyl)-2-(((4-(2-fluorophenyl)pyridin-3-yl)methyl)(propyl)amino)acetonitrile

2-(3,5-bis(trifluoromethyl)phenyl)-2-(((4-(2-fluorophenyl)pyridin-3-yl)methyl)(furan-2-ylmethyl)amino)acetonitrile

N-(3,5-Bis(trifluoromethyl)benzyl)-N-((4-(2-fluorophenyl)pyridin-3-yl)methyl)furan-2-carboxamide