ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(4-(trifluoromethyl)phenyl)cyclohexanecarboxylate

Base Information

Chemical Name:ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(4-(trifluoromethyl)phenyl)cyclohexanecarboxylate
CAS No.:1033363-14-2
Molecular Formula:C₁₉H₂₂F₃NO₆
Molecular Weight:417.382
Hs Code.:

Synonyms:ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(4-(trifluoromethyl)phenyl)cyclohexanecarboxylate

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Chemical Property of ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(4-(trifluoromethyl)phenyl)cyclohexanecarboxylate

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Technology Process of ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(4-(trifluoromethyl)phenyl)cyclohexanecarboxylate

There total 2 articles about ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(4-(trifluoromethyl)phenyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 35490-05-2
2-acetyl-5-oxohexanoic acid ethyl ester

: 93628-97-8,99696-01-2
1-(2-nitrovinyl)-4-trifluoromethylbenzene

: 1033363-14-2
ethyl (1R,2R,3S,4R)-1-acetyl-4-hydroxy-4-methyl-3-nitro-2-(4-(trifluoromethyl)phenyl)cyclohexanecarboxylate

Guidance literature:: With (R)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanamine; In diethyl ether; at 23 ℃; for 24h; optical yield given as %ee; stereoselective reaction;
DOI:10.1021/ol8007183