(2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

Base Information

Chemical Name:(2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate
CAS No.:1360743-28-7
Molecular Formula:C₁₄H₁₉N₃O₅
Molecular Weight:309.322
Hs Code.:

Synonyms:(2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

Suppliers and Price of (2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

There total 6 articles about (2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1360743-27-6
C₁₄H₁₈O₈S

: 1360743-28-7
(2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

Guidance literature:: C₁₄H₁₈O₈S; With sodium azide; In water; acetone; at 50 ℃; for 9h;

With sulfuric acid; In diethyl ether; water; at 0 - 20 ℃; for 12h; regioselective reaction;
DOI:10.1021/ol300293a

Reference yield:

: 1013326-37-8
(Z)-methyl 4-(4-methoxybenzyloxy)-3-methylbut-2-enoate

: 1360743-28-7
(2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: AD-mix-α; methanesulfonamide; water / tert-butyl alcohol / 96 h / -1 °C

2.1: thionyl chloride; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.1: sodium periodate; ruthenium trichloride / water; acetonitrile / 0.5 h / 0 °C

4.1: sodium azide / water; acetone / 9 h / 50 °C

4.2: 12 h / 0 - 20 °C

With ruthenium trichloride; sodium periodate; thionyl chloride; sodium azide; methanesulfonamide; AD-mix-α; water; triethylamine; In dichloromethane; water; acetone; acetonitrile; tert-butyl alcohol; 1.1: Sharpless dihydroxylation;
DOI:10.1021/ol300293a

Reference yield:

: 1360743-26-5
(2R,3R)-methyl 2,3-dihydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

: 1360743-28-7
(2S,3S)-methyl 2-azido-3-hydroxy-4-(4-methoxybenzyloxy)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.1: sodium periodate; ruthenium trichloride / water; acetonitrile / 0.5 h / 0 °C

3.1: sodium azide / water; acetone / 9 h / 50 °C

3.2: 12 h / 0 - 20 °C

With ruthenium trichloride; sodium periodate; thionyl chloride; sodium azide; triethylamine; In dichloromethane; water; acetone; acetonitrile;
DOI:10.1021/ol300293a