8-Phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide

Base Information

• Chemical Name: 8-Phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide
• CAS No.: 152534-41-3
• Molecular Formula: C₂₀H₂₇N₃O₂
• Molecular Weight: 341.453
• Mol file: 152534-41-3.mol

Synonyms:8-Phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide

Chemical Property of 8-Phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide

There total 4 articles about 8-Phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-1-(2,3-dihydro-3-oxopyridazin-6-yl)ethylamine hydrochloride (90175-94-3) + 8-phenyloctanoyl chloride (61875-56-7) → 8-Phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide (152534-41-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm00076a005

Reference yield:

5-Benzamido-4-oxohexansaeureethylester (68219-65-8) → 8-Phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide (152534-41-3)

Guidance literature:

Multi-step reaction with 4 steps

1: N₂H₄*H₂O / ethanol / Heating

2: Br₂, AcOH / 40 °C

3: 82 percent / 6M aq. HCl / 18 h / Heating

4: Et₃N / dimethylformamide / 24 h / 20 °C

With hydrogenchloride; bromine; hydrazine hydrate; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00076a005

Reference yield:

6-(1-benzoylamino-ethyl)-2H-pyridazin-3-one (68219-76-1) → 8-Phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide (152534-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / 6M aq. HCl / 18 h / Heating

2: Et₃N / dimethylformamide / 24 h / 20 °C

With hydrogenchloride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00076a005

upstream raw materials:

N-1-(2,3-dihydro-3-oxopyridazin-6-yl)ethylamine hydrochloride

8-phenyloctanoyl chloride

5-Benzamido-4-oxohexansaeureethylester

6-(1-benzoylamino-ethyl)-2H-pyridazin-3-one