N-(3-ethynylobenzoyl)-L-homoserine lactone

Base Information

Chemical Name:N-(3-ethynylobenzoyl)-L-homoserine lactone
CAS No.:1421345-00-7
Molecular Formula:C₁₃H₁₁NO₃
Molecular Weight:229.235
Hs Code.:

Synonyms:N-(3-ethynylobenzoyl)-L-homoserine lactone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-ethynylobenzoyl)-L-homoserine lactone

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Technology Process of N-(3-ethynylobenzoyl)-L-homoserine lactone

There total 4 articles about N-(3-ethynylobenzoyl)-L-homoserine lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1421344-98-0
N-(3-trimethylsilylethynylobenzoyl)-L-homoserine lactone

: 1421345-00-7
N-(3-ethynylobenzoyl)-L-homoserine lactone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1039/c2ob27155a

Reference yield:

: 618-51-9
3-Iodobenzoic acid

: 1421345-00-7
N-(3-ethynylobenzoyl)-L-homoserine lactone

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / dichloromethane / 5 h / 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 16 h / 20 °C / Schlenk technique; Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1039/c2ob27155a

Reference yield:

: 1421344-96-8
N-(3-iodobenzoyl)-L-homoserine lactone

: 1421345-00-7
N-(3-ethynylobenzoyl)-L-homoserine lactone

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 16 h / 20 °C / Schlenk technique; Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1039/c2ob27155a