Technology Process of C27H22BrN
There total 5 articles about C27H22BrN which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phosphorus tribromide;
In
tetrahydrofuran; diethyl ether;
at 0 - 20 ℃;
for 15h;
DOI:10.1021/ja309393c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / dichloromethane; methanol / 2 h / 20 °C
2.1: phosphorus tribromide / diethyl ether / 15 h / 0 - 20 °C
3.1: toluene / 24 h / Reflux
4.1: potassium tert-butylate / tetrahydrofuran / 3.67 h / Inert atmosphere; Reflux
4.2: 15 h / 0 - 20 °C / Inert atmosphere
5.1: sodium hydroxide; sodium tetrahydroborate / tetrahydrofuran; methanol; water / 15 h / 20 °C
6.1: phosphorus tribromide / tetrahydrofuran; diethyl ether / 15 h / 0 - 20 °C
With
sodium tetrahydroborate; potassium tert-butylate; phosphorus tribromide; sodium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene;
DOI:10.1021/ja309393c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: phosphorus tribromide / diethyl ether / 15 h / 0 - 20 °C
2.1: toluene / 24 h / Reflux
3.1: potassium tert-butylate / tetrahydrofuran / 3.67 h / Inert atmosphere; Reflux
3.2: 15 h / 0 - 20 °C / Inert atmosphere
4.1: sodium hydroxide; sodium tetrahydroborate / tetrahydrofuran; methanol; water / 15 h / 20 °C
5.1: phosphorus tribromide / tetrahydrofuran; diethyl ether / 15 h / 0 - 20 °C
With
sodium tetrahydroborate; potassium tert-butylate; phosphorus tribromide; sodium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; water; toluene;
DOI:10.1021/ja309393c
