α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester

Base Information

Chemical Name:α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester
CAS No.:125049-97-0
Molecular Formula:C₂₈H₄₇NO₇Si
Molecular Weight:537.769
Hs Code.:

Synonyms:α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester

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Chemical Property of α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester

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Technology Process of α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester

There total 7 articles about α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 125049-96-9
tert-butyl ester of α-N-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)-D-hydroxynorvaline

: 125049-97-0
α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester

Guidance literature:: With dmap; In acetonitrile; for 24h; Ambient temperature;
DOI:10.1021/jo00293a010

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 125049-97-0
α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

2: 1N NaOH / methanol / 1 h / Ambient temperature

3: Et₃N / tetrahydrofuran / 0.75 h / -20 °C

4: 87 percent / NaBH₄ / tetrahydrofuran; H₂O / 3 h / Ambient temperature

5: 98 percent / imidazole / dimethylformamide / Ambient temperature; further bases used

6: 93 percent / DMAP / acetonitrile / 24 h / Ambient temperature

With 1H-imidazole; dmap; sodium hydroxide; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00293a010

Reference yield:

: 125076-26-8
2-Benzyloxycarbonylamino-5-hydroxy-pentanoic acid tert-butyl ester

: 125049-97-0
α-carbo-tert-butoxy-α-carbobenzoxy-δ-O-(tert-butyldimethylsilyl)hydroxynorvaline tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / imidazole / dimethylformamide / Ambient temperature; further bases used

2: 93 percent / DMAP / acetonitrile / 24 h / Ambient temperature

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00293a010