N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol
CAS No.:653571-04-1
Molecular Formula:C₂₀H₃₀N₂O₄
Molecular Weight:362.469
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol

There total 4 articles about N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62-53-3
aniline

: 2,2-dimethyl-4-(2-oxo-ethyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester

: 653571-04-1
N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2003.09.020

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 653571-04-1
N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h / 20 °C

2: DIBALH / CH₂Cl₂ / 3 h / -78 °C

3: 61.2 mg / NaBH(OAc)3 / 1,2-dichloro-ethane / 3 h / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2003.09.020

Reference yield:

: 114364-62-4
ethyl 2,3,6-trideoxy-3,6-imino-4,5-O-isopropylidene-D-ribo-hexanoate

: 653571-04-1
N-(tert-butoxycarbonyl)-(2S,3S,4R)-2-[2-(phenylamino)ethyl]-3,4-O-isopropylidenepyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h / 20 °C

2: DIBALH / CH₂Cl₂ / 3 h / -78 °C

3: 61.2 mg / NaBH(OAc)3 / 1,2-dichloro-ethane / 3 h / 20 °C

With pyridine; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2003.09.020