Technology Process of 7-(4-chlorophenyl)-7-phenylheptanoic acid
There total 5 articles about 7-(4-chlorophenyl)-7-phenylheptanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hypochlorite; 2-methyl-but-2-ene; phosphate monobasic buffer;
In
water; tert-butyl alcohol;
at 20 ℃;
for 2h;
DOI:10.1016/j.bmc.2005.03.004
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / H2; formic acid / Pd/C / ethanol / 18 h
2: 65 percent / oxalyl chloride; DMSO; diisopropylethylamine / CH2Cl2 / -78 - 20 °C
3: 72 percent / sodium hypochlorite; phosphate monobasic buffer; 2-methyl-2-butene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C
With
sodium hypochlorite; formic acid; 2-methyl-but-2-ene; oxalyl dichloride; phosphate monobasic buffer; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
ethanol; dichloromethane; water; tert-butyl alcohol;
2: Swern oxidation;
DOI:10.1016/j.bmc.2005.03.004
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: BuLi / tetrahydrofuran / 1 h / 20 °C
1.2: 37 percent / tetrahydrofuran / 3 h / 0 °C
2.1: 100 percent / H2; formic acid / Pd/C / ethanol / 18 h
3.1: 65 percent / oxalyl chloride; DMSO; diisopropylethylamine / CH2Cl2 / -78 - 20 °C
4.1: 72 percent / sodium hypochlorite; phosphate monobasic buffer; 2-methyl-2-butene / H2O; 2-methyl-propan-2-ol / 2 h / 20 °C
With
sodium hypochlorite; n-butyllithium; formic acid; 2-methyl-but-2-ene; oxalyl dichloride; phosphate monobasic buffer; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; water; tert-butyl alcohol;
3.1: Swern oxidation;
DOI:10.1016/j.bmc.2005.03.004
