Sodium; 4-{3-[4-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-butyl]-thioureido}-benzenesulfonate

Base Information

• Chemical Name: Sodium; 4-{3-[4-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-butyl]-thioureido}-benzenesulfonate
• CAS No.: 85396-87-8
• Molecular Formula: C₂₁H₂₁N₄O₄S₂*Na
• Molecular Weight: 480.544
• Mol file: 85396-87-8.mol

Synonyms:Sodium; 4-{3-[4-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-butyl]-thioureido}-benzenesulfonate

Chemical Property of Sodium; 4-{3-[4-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-butyl]-thioureido}-benzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Sodium; 4-{3-[4-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-butyl]-thioureido}-benzenesulfonate

There total 3 articles about Sodium; 4-{3-[4-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-butyl]-thioureido}-benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

sodium 4-isothiocyanatobenzene-1-sulphonate (17614-69-6) + 2-(2-aminobutyl)-6-phenyl-3(2H)-pyridazinone (79460-62-1) → Sodium; 4-{3-[4-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-butyl]-thioureido}-benzenesulfonate (85396-87-8)

Guidance literature:

In chloroform; at 80 ℃; for 2h;

DOI:10.1021/jm00357a012

Reference yield:

6-phenylpyridazin-3(2H)-one (2166-31-6) → Sodium; 4-{3-[4-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-butyl]-thioureido}-benzenesulfonate (85396-87-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 89.5 percent / K₂CO₃ / various solvent(s) / 6 h / Heating

2: 1.) 100 percent hydrazine hydrate, 2.) 10 percent aq. HCl / 1.) EtOH, reflux, 4 h, 2.) EtOH, reflux, 2 h

3: 46 percent / CHCl₃ / 2 h / 80 °C

With hydrogenchloride; potassium carbonate; hydrazine hydrate; In chloroform;

DOI:10.1021/jm00357a012

Reference yield:

6-phenyl-2-<2-(phthalimido)butyl>-3(2H)-pyridazinone (79222-75-6) → Sodium; 4-{3-[4-(6-oxo-3-phenyl-6H-pyridazin-1-yl)-butyl]-thioureido}-benzenesulfonate (85396-87-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 100 percent hydrazine hydrate, 2.) 10 percent aq. HCl / 1.) EtOH, reflux, 4 h, 2.) EtOH, reflux, 2 h

2: 46 percent / CHCl₃ / 2 h / 80 °C

With hydrogenchloride; hydrazine hydrate; In chloroform;

DOI:10.1021/jm00357a012

upstream raw materials:

sodium 4-isothiocyanatobenzene-1-sulphonate

2-(2-aminobutyl)-6-phenyl-3(2H)-pyridazinone

6-phenylpyridazin-3(2H)-one

6-phenyl-2-<2-(phthalimido)butyl>-3(2H)-pyridazinone