5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(3-chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-amide

Base Information

• Chemical Name: 5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(3-chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-amide
• CAS No.: 1224943-37-6
• Molecular Formula: C₁₇H₁₄ClN₇O
• Molecular Weight: 367.797

Synonyms:5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(3-chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-amide

Chemical Property of 5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(3-chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-amide

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Technology Process of 5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(3-chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-amide

There total 9 articles about 5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(3-chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-chloro-N-(3-(3-chlorophenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (1224944-72-2) → 5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(3-chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-amide (1224943-37-6)

Guidance literature:

With ammonia; In ethanol; at 0 - 120 ℃; for 1.83333h; Microwave irradiation;

DOI:10.1021/jm3012239

Reference yield:

2-bromo-1-(3-chloro-phenyl)-ethanone (41011-01-2) → 5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(3-chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-amide (1224943-37-6)

Guidance literature:

Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 1 h / 50 °C

2: 18 h / 100 °C

3: ethanol / 2 h / 80 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

5: ammonia / ethanol / 1.83 h / 0 - 120 °C / Microwave irradiation

With ammonia; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm3012239

Reference yield:

2-(3-(3-chlorophenyl)-1-(dimethylamino)-3-oxoprop-1-en-2-yl)isoindoline-1,3-dione (1224944-70-0) → 5-amino-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(3-chloro-phenyl)-1-methyl-1H-pyrazol-4-yl]-amide (1224943-37-6)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 2 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

3: ammonia / ethanol / 1.83 h / 0 - 120 °C / Microwave irradiation

With ammonia; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1021/jm3012239

upstream raw materials:

2-bromo-1-(3-chloro-phenyl)-ethanone

5-chloro-N-(3-(3-chlorophenyl)-1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

3-iodopyrazolo[1,5-a]pyrimidin-5(4H)-one

methyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate

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